The expansion of MDSCs induced by exosomal PD-L1 promotes the progression of gastric cancer
Exosomal PD-L1 has the potential to become a prognostic and diagnostic biomarker for GC patients. Mechanistically, MDSCs can be activated by exosomal PD-L1 through IL-6/STAT3 signaling and provide a new strategy against GC through the use of exosomal PD-L1 as a treatment target.
Authors
- Xu Chen (ORCID: https://orcid.org/0000-0003-4735-2364)
- Yujia Lu
- Bo Han (ORCID: https://orcid.org/0000-0003-4966-1398)
- Huai Li (ORCID: https://orcid.org/0000-0001-7129-6660)
- Xufeng Hu
- Qingmin Sun (ORCID: https://orcid.org/0000-0002-4428-4637)
- Xiang Zhang (ORCID: https://orcid.org/0000-0002-6706-3925)
- Shanshan Zheng
- Xiaoxia Zheng
- Jian Wu (ORCID: https://orcid.org/0000-0002-1192-321X)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Yixing Tumor Hospital (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1186/s12967-024-05611-y
- Citations
- 26
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.25
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Jiangsu Provincial Medical Youth Talent