Role of sodium‐dependent vitamin C transporter 2 in human periodontal ligament fibroblasts
Our study reveals the SVCT2 expression in PDL and the pivotal role of SVCT2 in mediating AA-induced enhancements of ALP activity and collagen production in PDLF. Additionally, we identify alterations in gene expression profiles, highlighting potential molecular targets influenced by AA through SVCT2. These findings deepen our understanding of periodontal tissue homeostasis mechanisms and suggest promising intervention targeting AA metabolism.
Authors
- Yoichiro Taguchi (ORCID: https://orcid.org/0000-0002-6427-0232)
- Kengo Iwasaki (ORCID: https://orcid.org/0000-0002-0494-5760)
- Makoto Umeda (ORCID: https://orcid.org/0000-0002-9470-0045)
- Tomoko Kanda
Institutions
- Osaka Dental University (JP)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1111/jre.13322
- Citations
- 1
- Primary Topic
- Vitamin C and Antioxidants Research
- Type
- article
- Field-Weighted Citation Impact
- 0.31