Efficacy of Metformin plus Sodium Glucose Transporter-2 inhibitors (SGLT-2i) in Obese Type 2

IntroductionDiabetes mellitus type 2 is a clinical syndrome which encroaches any system of the body due to hyperglycemia and derangements of counter regulatory hormones.Due to the nature of this disease and high prevalence, Diabetes mellitus type 2 is projected as a big public 1 problem.The holistic approach is patient centered, used to treat type 2 diabetes, such as lifestyle modifications, self-blood glucose monitoring, and education about complications.The treatment includes oral antidiabetic drugs, insulin and insulin like agents; GLP1 agonists.However, an alternative, more intensive approach is initial combination treatment.Recently societies emphasized patient's Glycated hemoglobin (HbA1c) <7% for which initial combination therapy should be considered.Type 2 diabetes accounts for more than two third of cases among all diabetic subjects.The major problem is resistance to insulin or blunt response of insulin.The obesity is the main culprit of type 2 diabetes.Hence, if a diabetic patient will lose about 10% of body weight, remission from diabetes is possible.This overall reduces the associated cardiovascular events like fatal and non-2 fatal myocardial infarction.The proportion of people with type 2 diabetes is increasing in most countries, 79% of adults with diabetes are living in low and middle-income countries.The greatest