Beyond Conventional: Nanotechnology-driven Herbal Interventions in the Treatment of Polycystic Ovary Syndrome

Objective: In patients with PCOS, oxidative stress is caused by an imbalance between antioxidants and reactive oxygen species, which increases the risk of cardiovascular disease. Existing therapies, which mostly include synthetic medications, often result in serious adverse effects. Alternatively, a secure and efficient method of treating PCOS appears to be the mix of phytoconstituents and lifestyle changes. Methods: This review examines the global impact of PCOS, a prevalent hormonal disorder combining genetic, environmental, behavioral, and endocrine factors, and the potential side effects of synthetic medications used for its treatment. The authors conducted a narrative review using major databases like PubMed, ScienceDirect, and Google Scholar from October 1st to November 25th, 2023. They analyzed data from review articles, research articles, and meta-analyses published until August 2023 on pathogenesis, diagnosis, management, synthetic and herbal treatment, and nanotechnology effective in PCOS treatment, including those related to the theme. Results: PCOS affects women globally, and synthetic agents like insulin sensitizers, contraceptive pills, and anti-androgens may have numerous long-term health effects. A natural substitute for contemporary pharmaceuticals, herbal therapies are prized for their health benefits. Scientific studies support the safety and effectiveness of herbal bio-actives, which utilize diverse phytochemicals to reduce PCOS symptoms. Conclusion: To overcome the side effects of the synthetic agents, more influence is given to the natural way of curbing the syndrome for a healthier life. Thus, this review combines the potential advantages of utilizing various herbal plants for PCOS treatment by amalgamating findings from numerous literature studies.