MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model
Mouse models using transgenes which generate spontaneous cancers are essential tools to examine the etiology of human diseases. Here, the first Myc-driven spontaneous model is described as a valid HGSOC model. Surprisingly, aspects of uterine serous carcinoma were also observed in this model.
Authors
- Laura Spruill (ORCID: https://orcid.org/0000-0003-1895-5203)
- Shelby Carter
- Silvia G. Vaena
- George Fullbright (ORCID: https://orcid.org/0000-0003-0321-0559)
- Kristi L. Helke (ORCID: https://orcid.org/0000-0001-9746-0764)
- Robert R. Bowers (ORCID: https://orcid.org/0000-0003-1873-2114)
- David T. Long (ORCID: https://orcid.org/0000-0001-9232-0316)
- Brian Orr (ORCID: https://orcid.org/0000-0003-0158-1575)
- Anthony J. Emanuel (ORCID: https://orcid.org/0000-0003-2139-6422)
- Alexandra Blackman (ORCID: https://orcid.org/0000-0001-8841-124X)
- Joe Ryan Delaney (ORCID: https://orcid.org/0000-0002-8978-5961)
- Martin J. Romeo (ORCID: https://orcid.org/0000-0001-7941-1862)
- Richard L. Carpenter (ORCID: https://orcid.org/0000-0001-9986-6493)
- Christian M. Jones (ORCID: https://orcid.org/0000-0002-0914-2967)
- Amy C. Rees
- Della Evans
- Evan D. Villamor
- Madison A. Clark
- Matthew S. O’Malley
Institutions
- Medical University of South Carolina (US)
- MUSC Hollings Cancer Center (US)
- Indiana University Bloomington (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0144
- Citations
- 4
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.15