Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials
In these longitudinal trials, B12 levels were higher than for DATATOP, due in large part to increased B12-supplement intake, while tHcy levels were similar. Initiation of levodopa was associated with increases of tHcy in those not taking a B12-containing supplement. These smaller studies did not replicate prior findings of low B12 and elevated tHcy with features of progression, possibly due to higher baseline B12.
Authors
- Lyvin Tat (ORCID: https://orcid.org/0000-0002-2446-2088)
- Chadwick W. Christine (ORCID: https://orcid.org/0000-0003-4166-9432)
- David Oakes (ORCID: https://orcid.org/0000-0002-9154-6054)
- Esther Forti
- Jay M. Iyer
- Noemi Cannizzaro (ORCID: https://orcid.org/0009-0008-0071-6291)
- Peggy Auinger (ORCID: https://orcid.org/0000-0002-5262-8946)
- Ralph Green (ORCID: https://orcid.org/0000-0002-9935-230X)
- Arshi Mustafa
Institutions
- Harvard University (US)
- University of California, San Francisco (US)
- University of Rochester (US)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Parkinson s Disease
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3233/jpd-240035
- Citations
- 3
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke