Correlation between plasma ccfDNA, mtDNA changes, CTCs, and epithelial-mesenchymal transition in breast cancer patients undergoing NACT
This study represents the first comprehensive investigation of plasma ccfDNA levels, mtDNAcn, and integrities collectively. Furthermore, it is the first study to explore the relationship between these markers and CTCs, cancer stem cell markers, treatment response, and metastatic status. Our findings suggest that plasma ccfDNA and mtDNA may serve as potential biomarkers for assessing chemotherapy response and can be employed alone or in combination with other biomarkers to monitor treatment efficacy in breast cancer patients.
Authors
- Mustafa Akkіprіk (ORCID: https://orcid.org/0000-0002-1100-765X)
- Özkan Alan (ORCID: https://orcid.org/0000-0002-6635-2012)
- Betül Çelik (ORCID: https://orcid.org/0000-0001-7923-275X)
- Sinan Koca (ORCID: https://orcid.org/0000-0002-8370-1587)
- İrem Peker Eyüboğlu (ORCID: https://orcid.org/0000-0003-0764-9841)
- Mustafa Ümit Uğurlu (ORCID: https://orcid.org/0000-0002-4757-5560)
- Tuğba Akın Telli (ORCID: https://orcid.org/0000-0001-6535-6030)
- Gökçe Güllü Amuran (ORCID: https://orcid.org/0000-0002-2267-2110)
- Fulden Perran Yumuk
Institutions
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Marmara University (TR)
Publication Details
- Journal
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Published
- 2024-08-23
- DOI
- https://doi.org/10.55730/1300-0144.5834
- Citations
- 4
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- Marmara Üniversitesi