Limbic Network Derangement Mediates Unawareness of Apathy in Mild Cognitive Impairment due to Alzheimer’s Disease: Clues from [<sup>18</sup>F]FDG PET Voxel-Wise Analysis
Apathy unawareness entails early disruption of the limbic circuitry rather than the classical frontal-subcortical pathways typically associated with apathy. This reaffirms apathy unawareness as an early and independent measure in MCI-AD, marked by distinct pathophysiological alterations.
Authors
- Stefano Raffa
- Francesco Calizzano
- Enrico Peira (ORCID: https://orcid.org/0000-0002-5834-8101)
- Wendy Kreshpa (ORCID: https://orcid.org/0009-0004-6810-4815)
- Angelo E. Schenone (ORCID: https://orcid.org/0000-0002-2604-7830)
- Gianmario Sambuceti (ORCID: https://orcid.org/0000-0003-2979-6500)
- Fiammetta Monacelli (ORCID: https://orcid.org/0000-0003-4303-7252)
- Massimo Del Sette (ORCID: https://orcid.org/0000-0002-4551-0675)
- Paola Mandich (ORCID: https://orcid.org/0000-0003-3123-3512)
- Pietro Mattioli (ORCID: https://orcid.org/0000-0003-2563-5830)
- Andrea Brugnolo (ORCID: https://orcid.org/0000-0002-5708-0940)
- Pietro Calcagno (ORCID: https://orcid.org/0000-0003-2007-2311)
- Nicola Girtler (ORCID: https://orcid.org/0000-0001-8119-8642)
- Stefano Pretta
- Federico Massa (ORCID: https://orcid.org/0000-0001-5667-204X)
- Matteo Pardini (ORCID: https://orcid.org/0000-0002-4740-1982)
- Gianluca Serafini (ORCID: https://orcid.org/0000-0002-6631-856X)
- Fabio Gotta
- A. Chincarini (ORCID: https://orcid.org/0000-0003-4094-9942)
- Dario Arnaldi (ORCID: https://orcid.org/0000-0001-6823-6069)
- Silvia Daniela Morbelli (ORCID: https://orcid.org/0000-0002-7833-6095)
- Beatrice Orso (ORCID: https://orcid.org/0000-0001-9983-7940)
- Luca Tagliafico (ORCID: https://orcid.org/0000-0003-2372-9999)
- Luca Sofia
Institutions
- Istituto Nazionale di Fisica Nucleare (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Ospedale Policlinico San Martino (IT)
- University of Turin (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3233/jad-240430
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.77