Supramolecular hydrogel of mycophenolic acid for treating allergic conjunctivitis
Mycophenolic acid (MPA) is an immunosuppressant less commonly utilized in allergic conjunctivitis. Peptide-based hydrogels improve material performance and are used in different biomedical applications. The current study reported that a cationic peptide Nap-FFKK and MPA were co-assembled into K–M hydrogel for sustained MPA delivery. The study evaluated cytotoxicity in vitro and its effectiveness in alleviating allergic conjunctivitis symptoms with a model. The current study demonstrates a promising strategy for using peptides as vehicles for sustained MPA delivery to the eye for ophthalmic applications.
Authors
- Ping Lu (ORCID: https://orcid.org/0000-0002-5107-4806)
- Guojuan Pu (ORCID: https://orcid.org/0009-0005-6016-5733)
- Jieran Shi
- Huiling Qing (ORCID: https://orcid.org/0000-0001-6440-3181)
- Tao Yuan (ORCID: https://orcid.org/0000-0003-3012-1324)
- Huiyun Xia (ORCID: https://orcid.org/0000-0001-8391-4294)
- Junjie Zhang (ORCID: https://orcid.org/0000-0003-0394-0316)
- Zhen Liang (ORCID: https://orcid.org/0009-0004-5737-1037)
Institutions
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Henan Provincial Eye Hospital (CN)
Publication Details
- Journal
- Journal of Drug Delivery Science and Technology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1016/j.jddst.2024.106152
- Citations
- 1
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.40