Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit
Multiplex-based serological surveillance is a valuable but underutilized tool to understand gaps in population-level exposure, susceptibility, and immunity to infectious diseases. Assays for which blood samples can be tested for antibodies against several pathogens simultaneously, such as multiplex bead immunoassays, can more efficiently integrate public health surveillance in low- and middle-income countries. On March 7-8, 2023 a group of experts representing research institutions, multilateral organizations, private industry, and country partners met to discuss experiences, identify challenges and solutions, and create a community of practice for integrated, multi-pathogen serosurveillance using multiplex bead assay technologies. Participants were divided into six working groups: 1) supply chain; 2) laboratory assays; 3) seroepidemiology; 4) data analytics; 5) sustainable implementation; and 6) use case scenarios. These working groups discussed experiences, challenges, solutions, and research needs to facilitate integrated, multi-pathogen serosurveillance for public health. Several solutions were proposed to address challenges that cut across working groups.
Authors
- Diana L. Martin (ORCID: https://orcid.org/0000-0001-9417-5562)
- Natalya Kostandova (ORCID: https://orcid.org/0000-0002-6184-531X)
- Sonia T. Hegde (ORCID: https://orcid.org/0000-0001-6426-0096)
- Richelle C. Charles (ORCID: https://orcid.org/0000-0002-8881-1849)
- E. Wangeci Kagucia (ORCID: https://orcid.org/0000-0002-4481-8889)
- Daniel T. Leung (ORCID: https://orcid.org/0000-0001-8401-0801)
- Christopher D. Heaney (ORCID: https://orcid.org/0000-0003-3211-8495)
- Christopher J. Drakeley
- Amy K. Winter (ORCID: https://orcid.org/0000-0003-2737-7003)
- Thomas Jaenisch (ORCID: https://orcid.org/0000-0002-9464-571X)
- Saki Takahashi (ORCID: https://orcid.org/0000-0001-5413-5507)
- Sammy M. Njenga (ORCID: https://orcid.org/0000-0001-6309-476X)
- Alex C. Kong (ORCID: https://orcid.org/0009-0002-5771-2757)
- Andrew S. Azman (ORCID: https://orcid.org/0000-0001-8662-9077)
- Isabel Rodríguez-Barraquer (ORCID: https://orcid.org/0000-0001-6784-1021)
- Amy Wesolowski (ORCID: https://orcid.org/0000-0001-6320-3575)
- Nicole Wolter (ORCID: https://orcid.org/0000-0002-9526-0133)
- May Chu (ORCID: https://orcid.org/0000-0002-7896-0496)
- Fiona R.M. van der Klis (ORCID: https://orcid.org/0000-0002-6759-3539)
- Martha-Idalí Saboyá-Díaz
- Emily S. Gurley (ORCID: https://orcid.org/0000-0002-8648-9403)
- Kondwani Jambo (ORCID: https://orcid.org/0000-0002-3195-2210)
- Andrea C. Carcelen (ORCID: https://orcid.org/0000-0001-6271-6387)
- Rosemary Rochford (ORCID: https://orcid.org/0000-0002-0001-5152)
- William J. Moss (ORCID: https://orcid.org/0000-0001-6579-3513)
- Henrik Salje (ORCID: https://orcid.org/0000-0003-3626-4254)
- Gerco den Hartog
Institutions
- National Health Laboratory Service (ZA)
- Centers for Disease Control and Prevention (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Radboud University Nijmegen (NL)
- University of Liverpool (GB)
- Colorado School of Public Health (US)
- University of Georgia (US)
- University of California, San Francisco (US)
- University of the Witwatersrand (ZA)
- Liverpool School of Tropical Medicine (GB)
- University of Utah (US)
- University of Cambridge (GB)
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme (MW)
- Radboud University Medical Center (NL)
- Kenya Medical Research Institute (KE)
- Massachusetts General Hospital (US)
- World Health Organization Regional Office for the Americas (US)
- London School of Hygiene & Tropical Medicine (GB)
- National Institute for Public Health and the Environment (NL)
- University Hospital of Geneva (CH)
- Division of Parasitic Diseases and Malaria (US)
Publication Details
- Journal
- American Journal of Tropical Medicine and Hygiene
- Published
- 2024-09-03
- DOI
- https://doi.org/10.4269/ajtmh.24-0296
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Bill and Melinda Gates Foundation
- Johns Hopkins University
- Centers for Disease Control and Prevention
- Johns Hopkins Bloomberg School of Public Health
- Pan American Health Organization