Cs<sub>2</sub>CO<sub>3</sub> Promoted [4 + 2] Cycloaddition of 1,6-Enynes: An Approach to Tetrahydro-1<i>H</i>-benzo-<i>f</i>-isoindole Isomers
A Cs<sub>2</sub>CO<sub>3</sub>-promoted [4 + 2] cycloaddition of 1,6-enynes under mild reaction conditions has been developed. This protocol provides a facile approach to a series of tetrahydro-1<i>H</i>-benzo[<i>f</i>]isoindole isomerized products promoted by Cs<sub>2</sub>CO<sub>3</sub> with moderate to high yields. By simply switching the reaction solvent and controlling the reaction time, two isomerization products could be obtained, both with good selectivity.
Authors
- Shuang Wu (ORCID: https://orcid.org/0000-0003-2579-9309)
- Yang’en You (ORCID: https://orcid.org/0009-0004-2945-7079)
- Junhao Yin
- Wangqin Mao
- Xu Wang (ORCID: https://orcid.org/0000-0002-2092-4054)
- Zhenyu Wang (ORCID: https://orcid.org/0000-0002-6250-1201)
Institutions
- Hefei University of Technology (CN)
- Nanchang Hangkong University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1021/acs.orglett.4c02927
- Citations
- 6
- Primary Topic
- Synthesis and pharmacology of benzodiazepine derivatives
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- National Natural Science Foundation of China
- Jiangxi Provincial Department of Science and Technology
- Anhui Postdoctoral Science Foundation
- Natural Science Foundation of Anhui Province
- Fundamental Research Funds for the Central Universities
- Chunhui Project Foundation of the Education Department of China