Norovirus-mediated translation repression promotes macrophage cell death

Norovirus infection is characterised by a rapid onset of disease and the development of debilitating symptoms including projectile vomiting and diffuse diarrhoea. Vaccines and antivirals are sorely lacking and developments in these areas are hampered by the lack of an adequate cell culture system to investigate human norovirus replication and pathogenesis. Herein, we describe how the model norovirus, Mouse norovirus (MNV), produces a viral protein, NS3, with the functional capacity to attenuate host protein translation which invokes the activation of cell death via apoptosis. We show that this function of NS3 is conserved between human and mouse viruses and map the protein domain attributable to this function. Our study highlights a critical viral protein that mediates crucial activities during replication, potentially identifying NS3 as a worthy target for antiviral drug development.

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Publication Details

Journal
PLoS Pathogens
Published
2024-09-03
DOI
https://doi.org/10.1371/journal.ppat.1012480
Citations
5
Primary Topic
Viral gastroenteritis research and epidemiology
Type
article
Field-Weighted Citation Impact
1.95

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article

Norovirus-mediated translation repression promotes macrophage cell death

Julio Carrera Montoya, Jennifer Hyde, Svenja Fritzlar, Jaclyn S. Pearson et al.
5 citations
PLoS Pathogens
Viral gastroenteritis research and epidemiology
1.95
article

Norovirus-mediated translation repression promotes macrophage cell death

Julio Carrera Montoya, Jennifer Hyde, Svenja Fritzlar, Jaclyn S. Pearson, Turgut E. Aktepe, Peter A. White, Joshua M. Deerain, Jason M. Mackenzie, Abderrahman Hachani, Eleanor M. Mead
article en
5 citations

Abstract

Norovirus infection is characterised by a rapid onset of disease and the development of debilitating symptoms including projectile vomiting and diffuse diarrhoea. Vaccines and antivirals are sorely lacking and developments in these areas are hampered by the lack of an adequate cell culture system to investigate human norovirus replication and pathogenesis. Herein, we describe how the model norovirus, Mouse norovirus (MNV), produces a viral protein, NS3, with the functional capacity to attenuate host protein translation which invokes the activation of cell death via apoptosis. We show that this function of NS3 is conserved between human and mouse viruses and map the protein domain attributable to this function. Our study highlights a critical viral protein that mediates crucial activities during replication, potentially identifying NS3 as a worthy target for antiviral drug development.

PLoS PathogensVol. 20(9)
The University of Melbourne (AU), University of Washington (US), Hudson Institute of Medical Research (AU), UNSW Sydney (AU), Peter Doherty Institute (AU)
University of Melbourne, University of Queensland, National Institutes of Health, Medical Research Council, National Health and Medical Research Council
Good health and well-being
Openalex Percentile: Top 14%
Viral gastroenteritis research and epidemiology
1.95
DOIOpen Access PDFOpenAlex
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Norovirus-mediated translation repression promotes macrophage cell death — Julio Carrera Montoya, Jennifer Hyde, et al. · PLoS Pathogens (2024) | TGRS Research Map | TGRS