CCL22 as an independent prognostic factor in endometrial cancer patients
Our study suggests that CCL22 in EC is associated with OS, dependent on its location and the cell type producing it. Intracellular upregulation and extracellular secretion must be considered separately when investigating CCL22 expressing cell types in EC. These results may provide evidence for CCL22-mediated Treg recruitment in EC as a potential future therapeutic target.
Authors
- Stefanie Corradini (ORCID: https://orcid.org/0000-0001-8709-7252)
- M Mannewitz
- Mirjana Kessler (ORCID: https://orcid.org/0000-0002-9879-1052)
- Carolin Perleberg
- Udo Jeschke (ORCID: https://orcid.org/0000-0003-2623-3235)
- Sven Mahner (ORCID: https://orcid.org/0000-0002-0640-129X)
- Sarah Meister (ORCID: https://orcid.org/0000-0002-1950-2006)
- Sophie Mitter
- Elisa Schmoeckel (ORCID: https://orcid.org/0000-0001-7199-3837)
- Laura Hahn (ORCID: https://orcid.org/0000-0003-3119-6053)
- Susanne Beyer (ORCID: https://orcid.org/0000-0001-8603-6714)
- Fabian Trillsch (ORCID: https://orcid.org/0000-0002-1860-4350)
- Thomas Kolben
Institutions
- Center for Integrated Protein Science Munich (DE)
- University Hospital Augsburg (DE)
- LMU Klinikum (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1016/j.tranon.2024.102116
- Citations
- 2
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Ludwig-Maximilians-Universität München