Synthesis of FSO2-Functionalized Oxindoles via a Radical Fluorosulfonylation/Intramolecular Arylation Cascade
Abstract Herein, we report the development of a FSO2 radical initiated tandem cyclization reaction under visible light photoredox catalysis, which allows for a facile access to FSO2-functionalized oxindoles from N-arylacrylamides. This reaction features mild reaction conditions, readily available starting materials, and SuFExable products. The introduction of sulfonyl fluoride groups into oxindoles could be of interest for related study in the context of discovering new bioactive molecules.
Authors
- Saihu Liao (ORCID: https://orcid.org/0000-0002-0251-8757)
- Junwei Han (ORCID: https://orcid.org/0000-0002-8419-3668)
- Na Yang (ORCID: https://orcid.org/0009-0009-6180-185X)
- Guanhua Pei
- Hao Li (ORCID: https://orcid.org/0000-0002-7577-1366)
- Lili Xie (ORCID: https://orcid.org/0009-0003-4173-9741)
- Peng Wang (ORCID: https://orcid.org/0000-0003-1824-2545)
Institutions
- Huaibei Normal University (CN)
- Xiamen University (CN)
- Collaborative Innovation Center of Chemistry for Energy Materials (CN)
- Chemical Synthesis Lab (SG)
- Fuzhou University (CN)
Publication Details
- Journal
- Synthesis
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1055/a-2409-5678
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fuzhou University
- Xiamen University
- Recruitment Program of Global Experts