HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis

lncRNA can regulate tumorigenesis development and distant metastasis of colorectal cancer (CRC). However, the detailed molecular mechanisms are still largely unknown. Using RNA-sequencing data, RT-qPCR, and FISH assay, we found that HIF1A-AS2 was upregulated in CRC tissues and associated with poor prognosis. Functional experiments were performed to determine the roles of HIF1A-AS2 in tumor progression and we found that HIF1A-AS2 can promote the proliferation, metastasis, and aerobic glycolysis of CRC cells. Mechanistically, HIF1A-AS2 can promote FOXC1 expression by sponging miR-141-3p. SP1 can transcriptionally activate HIF1A-AS2. Further, HIF1A-AS2 can be packaged into exosomes and promote the malignant phenotype of recipient tumor cells. Taken together, we discovered that SP1-induced HIF1A-AS2 can promote the metabolic reprogramming and progression of CRC via miR-141-3p/FOXC1 axis. HIF1A-AS2 is a promising diagnostic marker and treatment target in CRC.

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Publication Details

Journal
Cell Death and Disease
Published
2024-09-03
DOI
https://doi.org/10.1038/s41419-024-06958-2
Citations
10
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
2.85

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article

HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis

Dawei Li, Senlin Zhao, Huixia Huang, Zijuan Hu et al.
10 citations
Cell Death and Disease
Cancer-related molecular mechanisms research
2.85
article

HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p/FOXC1 axis

Dawei Li, Senlin Zhao, Huixia Huang, Zijuan Hu, Xinyang Zhong, Jiayu Chen, Ping Wei, Keji Chen, Yaxian Wang, Xuefeng He, Xinxin He, Bo Feng, Yilin Wang, Hong Zhang
article en
10 citations

Abstract

lncRNA can regulate tumorigenesis development and distant metastasis of colorectal cancer (CRC). However, the detailed molecular mechanisms are still largely unknown. Using RNA-sequencing data, RT-qPCR, and FISH assay, we found that HIF1A-AS2 was upregulated in CRC tissues and associated with poor prognosis. Functional experiments were performed to determine the roles of HIF1A-AS2 in tumor progression and we found that HIF1A-AS2 can promote the proliferation, metastasis, and aerobic glycolysis of CRC cells. Mechanistically, HIF1A-AS2 can promote FOXC1 expression by sponging miR-141-3p. SP1 can transcriptionally activate HIF1A-AS2. Further, HIF1A-AS2 can be packaged into exosomes and promote the malignant phenotype of recipient tumor cells. Taken together, we discovered that SP1-induced HIF1A-AS2 can promote the metabolic reprogramming and progression of CRC via miR-141-3p/FOXC1 axis. HIF1A-AS2 is a promising diagnostic marker and treatment target in CRC.

Cell Death and DiseaseVol. 15(9)
Shanghai Medical College of Fudan University (CN), Guangxi Medical University (CN), Fudan University (CN), Ruijin Hospital (CN), Fudan University Shanghai Cancer Center (CN), Second Affiliated Hospital of Zhejiang University (CN), China Medical University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 8%
Cancer-related molecular mechanisms research
2.85
DOIOpen Access PDFOpenAlex
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