Clostridium autoethanogenum alters cofactor synthesis, redox metabolism, and lysine-acetylation in response to elevated H2:CO feedstock ratios for enhancing carbon capture efficiency
This research delves into the intricate dynamics of carbon fixation in C. autoethanogenum, examining the influence of highly elevated H<sub>2</sub>:CO ratios on metabolic processes and product outcomes. The study underscores the significance of optimizing gas feed composition for enhanced industrial efficiency, shedding light on potential mechanisms, such as post-translational modifications (PTMs), to fine-tune enzymatic activities and improve desired product yields.
Authors
- Robert L. Hettich (ORCID: https://orcid.org/0000-0001-7708-786X)
- Madhavi Z. Martin (ORCID: https://orcid.org/0000-0002-6677-2180)
- Steven D. Brown (ORCID: https://orcid.org/0000-0002-9281-3898)
- Richard J. Giannone (ORCID: https://orcid.org/0000-0001-8551-0138)
- Nancy L. Engle (ORCID: https://orcid.org/0000-0003-0290-7987)
- Dana L. Carper (ORCID: https://orcid.org/0000-0002-4758-8054)
- Michael E. Martin
- R. Adam Thompson (ORCID: https://orcid.org/0000-0002-9862-4801)
- Timothy James Tschaplinski (ORCID: https://orcid.org/0000-0002-9540-6622)
- Megan E. Davin (ORCID: https://orcid.org/0000-0003-4938-5952)
- Lucas W. Mendelson
Institutions
- Oak Ridge National Laboratory (US)
- AZ Technology (United States) (US)
- University of Tennessee at Knoxville (US)
Publication Details
- Journal
- Biotechnology for Biofuels and Bioproducts
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1186/s13068-024-02554-w
- Citations
- 16
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- U.S. Department of Energy
- Battelle
- UT-Battelle
- Advanced Research Projects Agency - Energy
- Advanced Research Projects Agency