Ectopic Production of Parathyroid Hormone and Production of Parathyroid Hormone-related Protein in Dedifferentiated Endometrial Carcinoma Induced Severe Hypercalcemia
Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormone-related peptide (PTHrP) and, rarely, by parathyroid hormone (PTH) production from tumors. We report a case of severe hypercalcemia in a woman with uterine cancer who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma. Postoperatively, PTH and PTHrP levels normalized but subsequently increased due to metastases. A molecular analysis confirmed the expression of the PTH gene and protein within the tumor, indicating ectopic PTH production. In diagnosing and treating cancers, it is necessary to consider not only PTHrP production but also ectopic PTH production.
Authors
- Hirofumi Watanabe (ORCID: https://orcid.org/0000-0003-2277-2784)
- Tadashi Otsuka (ORCID: https://orcid.org/0000-0002-0572-3764)
- Kazuki Watanabe (ORCID: https://orcid.org/0009-0003-9194-0961)
- Ryo Aida
- Hideyuki Kabasawa (ORCID: https://orcid.org/0009-0005-2159-7971)
- Ryohei Kaseda
- Ichiei Narita (ORCID: https://orcid.org/0000-0001-7692-3096)
- Akiko Kobayashi (ORCID: https://orcid.org/0000-0001-5200-8328)
- Megumi Kurosawa
- Shoko Yamazaki (ORCID: https://orcid.org/0000-0001-5808-7709)
- Hajime Umezu
- Kosuke Yoshihara
- Naofumi Imai
- Suguru Yamamoto (ORCID: https://orcid.org/0000-0002-8279-2966)
- Shin Goto (ORCID: https://orcid.org/0000-0002-6167-555X)
- Takahiro Taguchi
- Takeru Ogino
Institutions
- Niigata University Medical and Dental Hospital (JP)
- Niigata University (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2024-09-03
- DOI
- https://doi.org/10.2169/internalmedicine.3899-24
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00