Study on molecular mechanism of intervertebral disc degeneration by single cell hdWGCNA combined with transcriptome sequencing
Our study identified the Chond2 cell subtype associated with IVDD and selected four feature genes influencing the development of IVDD, namely IGFBP3, ACAN, VAPA and TMEM45A. Our findings establish a robust theoretical foundation for the clinical diagnosis and treatment of IVDD patients.
Authors
- Xiaolong Chen (ORCID: https://orcid.org/0000-0003-2083-0549)
- Shibao Lu (ORCID: https://orcid.org/0000-0002-8615-2229)
- Xuan Zhao (ORCID: https://orcid.org/0009-0002-2020-752X)
- Qijun Wang
- Wei Wang (ORCID: https://orcid.org/0000-0003-1568-222X)
Institutions
- Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
Publication Details
- Journal
- Non-coding RNA Research
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1016/j.ncrna.2024.09.003
- Citations
- 8
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.40