Direct Ingestion of Oxidized Red Blood Cells (Efferocytosis) by Hepatocytes
We here demonstrate that hepatocytes can directly ingest and degrade oxidized RBCs through efferocytosis, a process that can be also triggered by ethanol, heme and bilirubin. Our findings are highly suggestive for a novel mechanism of hepatic iron overload in ALD patients.
Authors
- Sebastian Mueller (ORCID: https://orcid.org/0000-0001-5655-6778)
- Anne Dropmann
- Chaowen Zheng (ORCID: https://orcid.org/0000-0001-6165-4647)
- Johannes Mueller (ORCID: https://orcid.org/0000-0002-5205-4129)
- Seddik Hammad (ORCID: https://orcid.org/0000-0003-4067-8492)
- Songqing He (ORCID: https://orcid.org/0000-0002-8375-4048)
- Steven Dooley
- Siyuan Li (ORCID: https://orcid.org/0009-0003-5648-0760)
- Cheng Chen (ORCID: https://orcid.org/0000-0002-6040-6833)
- Huanran Lyu
Institutions
- Guangxi Medical University (CN)
- South Valley University (EG)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- First Affiliated Hospital of GuangXi Medical University (CN)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Hepatic Medicine Evidence and Research
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/hmer.s469990
- Citations
- 3
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- China Scholarship Council
- Higher Education Discipline Innovation Project