Association of Polymorphic Cytochrome P450 Enzyme Pathways with Falls in Multimedicated Older Adults
This study suggests an association between the occurrence of falls in older adults and the metabolic capacity of CYP2C19. Thus, an important step toward prevention of falls might be to personalize dosage and treatment length of the main drug classes known to be CYP2C19 substrates, such as many antidepressants, opioids, and sedatives, but also proton pump inhibitors in particular in poor and intermediate metabolizers.
Authors
- Michael Steffens (ORCID: https://orcid.org/0000-0002-6445-8593)
- Michael Denkinger (ORCID: https://orcid.org/0000-0002-8097-060X)
- Katja Susanne Just (ORCID: https://orcid.org/0000-0002-6782-8078)
- J Sommer (ORCID: https://orcid.org/0009-0001-1582-2264)
- Catharina Scholl (ORCID: https://orcid.org/0000-0002-1463-5619)
- Dhayana Dallmeier (ORCID: https://orcid.org/0000-0003-3665-7023)
- Julia Stingl (ORCID: https://orcid.org/0000-0002-1566-8156)
- Dietrich Rothenbacher (ORCID: https://orcid.org/0000-0002-3563-2791)
- Laura M. Pott
Institutions
- Boston University (US)
- Federal Institute for Drugs and Medical Devices (DE)
- Universität Ulm (DE)
- Zimmer Biomet (Germany) (DE)
- Agaplesion Bethesda Klinik (DE)
- University Hospital Ulm (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Journal of the American Medical Directors Association
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1016/j.jamda.2024.105235
- Citations
- 2
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Deutsche Forschungsgemeinschaft
- Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg