Effects of FGF21 overexpression in osteoporosis and bone mineral density: a two-sample, mediating Mendelian analysis
Our study suggests that the overexpression of FGF21 may lead to a decrease in bone mineral density and increase the risk of osteoporosis, and the effect of FGF21 on osteoporosis may be mediated through type 2 diabetes and basal metabolic rate. This study can provide a reference for analyzing the potential mechanism of osteoporosis and is of great significance for the prevention and treatment of osteoporosis.
Authors
- Qiaojun Chen (ORCID: https://orcid.org/0000-0002-6496-0575)
- Yunjia Li (ORCID: https://orcid.org/0000-0002-5728-9795)
- Zhengchang Yang
- Jun Jiang (ORCID: https://orcid.org/0000-0002-6342-165X)
- Xiaowei Wang (ORCID: https://orcid.org/0000-0001-7273-1062)
- Jingjing Liu (ORCID: https://orcid.org/0000-0002-5331-7015)
- Zewei He
- Lirong Yang (ORCID: https://orcid.org/0000-0002-8270-3214)
- X Luo (ORCID: https://orcid.org/0009-0001-0131-7769)
- Ting Yang (ORCID: https://orcid.org/0009-0004-2335-3527)
- Na Qiang (ORCID: https://orcid.org/0000-0002-9849-4808)
- Yanfa Lei
- Changtao Lao
Institutions
- Kunming Medical University (CN)
- Second People's Hospital of Yunnan Province (CN)
- Sixth Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.3389/fendo.2024.1439255
- Citations
- 6
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40