Breaking barriers: the role of NETosis in blood-brain barrier leakage and age-related cognitive decline

Cognitive impairment is a common age-related comorbidity with blood-brain barrier (BBB) leakage a key event. BBB leakage increases with age, but the mechanisms are still not completely understood. In the current article, we briefly discussed the role of neutrophil extracellular traps (NETs) in age-associated increase in cognitive impairment. NETosis is a process neutrophils release web-like structures called NETs composed of DNA, histones, and antimicrobial proteins. These NETs act as physical barriers to trap and kill pathogens, such as bacteria, viruses, and fungi. Excessive NETs formation has been associated with various pathological conditions such as thrombosis, cancer metastasis, inflammatory diseases, and autoimmune disorders. Recent studies further indicated that NETosis plays a key role in the BBB leakage during stroke and depletion of neutrophils can attenuate the pathology of Alzheimer’s disease (AD) in murine models. In the current article, we briefly discussed the putative role of NETosis in BBB leakage and age-related cognitive impairment. It should briefly summarize the main content of the article, and it may include the background, purpose, significance, methods and conclusions of the article.