Machine learning and single-cell analysis identify the mitophagy-associated gene TOMM22 as a potential diagnostic biomarker for intervertebral disc degeneration
Our findings revealed that mitophagy may be used in the diagnosis of intervertebral disc degeneration and its typing, and TOMM22 is a molecule in this regard and may act as a potential diagnostic marker in intervertebral disc degeneration.
Authors
- Jianguang Xu (ORCID: https://orcid.org/0000-0002-9405-5453)
- Yinghao Wu (ORCID: https://orcid.org/0000-0003-1181-5670)
- Shengting Wu
- Hou‐Yong Yu (ORCID: https://orcid.org/0000-0002-6543-5924)
- Zhiheng Chen (ORCID: https://orcid.org/0000-0002-9756-3816)
- Xiaofeng Lian (ORCID: https://orcid.org/0000-0003-4089-9738)
- Guowang Zhang (ORCID: https://orcid.org/0000-0001-9615-8547)
- Erzhu Yang
Institutions
- Bengbu Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37378
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00