Metformin reduces testosterone level in type 2 diabetes mellitus patients and its therapy by traditional medicine

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia. Metformin, a commonly prescribed treatment for T2DM, is known for its effectiveness in improving glycemic control. Recent studies suggest that metformin may also influence testosterone levels in male patients, a hormone crucial for male reproductive health, muscle mass maintenance, and overall quality of life.Medicinal plants were traditionally used for influencing the testosterone level in the body which may be given as a therapy for the side – effects of metformin tablet. To assess the impact of metformin treatment on testosterone levels in male patients with Type 2 Diabetes Mellitus compared to non-diabetic males, and to evaluate the potential traditional medical treatment methods consequences of reduced testosterone levels. This projection is a prospective observational study conducted among 60 patients total divided into 30 males taking metformin as a hyperglycaemic agent with Type 2 Diabetes Mellitus and 30 males without any diabetic treatment will be carried out in different out-patient department of Shri MahantIndiresh Hospital, Patel Nagar, Dehradun to assess the level of testosterone in Type 2 Diabetes Mellitus taking metformin and in Non-Diabetic treatment. And based on this, more methods of traditional medicines for reducing testosterone levels were summarized. It was demonstrated that the type 2 diabetes mellitus male patients who are being treated with metformin are associated with significantly reduction in testosterone serum levels when compared to non-diabetic patients.Several plants were examinedand clinically studies were performed on them. It was discovered that these plants have been effective in increasing the testosterone level, which may be given as a therapy to help the patients. In aspects of this study shows reduction in the testosterone levels which may lead to low sex drives and induction of low testosterone induced erectile dysfunction. Metformin is used to treat T2DM along with-it, it decreases testosterone levels which impacts on the lifestyle of patients. So, there is essential need to further study the effect of metformin on testosterone levels in patients with T2DM. Additionally, plants that may be useful in increasing the testosterone levels should be studied further for their beneficial characteristics and potential therapeutic applications.