Persteroid, a new steroid from the marine-derived fungus <i>Penicillium</i> sp. ZYX-Z-143
A new steroid named persteroid (<b>1</b>) and seven known compounds (<b>2</b>-<b>8</b>) were isolated from the marine-derived fungus <i>Penicillium</i> sp. ZYX-Z-143. The structure of <b>1</b> was determined by HRESIMS, NMR, and ECD calculations. Compound <b>1</b> showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC<sub>50</sub> value of 46.31 ± 0.52 μM. Moreover, compound <b>1</b> potently suppressed nitric oxide (NO) production on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The cytotoxicity and antibacterial activity of all isolates were tested.
Authors
- Lu-Ting Dai (ORCID: https://orcid.org/0000-0003-2281-450X)
- You‐Xing Zhao
- Zhifang Yu (ORCID: https://orcid.org/0000-0003-0576-1186)
- Jiao-Cen Guo
- Qing‐Yun Ma
- Zi-Peng Wang
- Li Yang (ORCID: https://orcid.org/0000-0003-0638-5696)
- Qingyi Xie
- Hao-Fu Dai
Institutions
- Chinese Academy of Tropical Agricultural Sciences (CN)
- Nanjing Agricultural University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1080/14786419.2024.2394834
- Citations
- 6
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.69