Screening for Fabry Disease in Patients with Left Ventricular Hypertrophy in China: A Multicentre and Prospective Study
This pioneering screening study for FD among Chinese patients with unexplained LVH using DBS measurement, revealed an FD detection rate of 0.88%. Our findings confirmed that the combined measurement of lyso-Gb3 and α-Gal A activity is beneficial for primary screening of FD in patients with LVH. Given the availability of efficacious therapies and the value of cascade screening in extended families, early detection of FD in LVH patients is clinically important.
Authors
- Xiaoping Ji (ORCID: https://orcid.org/0009-0000-2508-7788)
- Miao Dong-xia
- Huixia Lu (ORCID: https://orcid.org/0000-0003-0131-5808)
- Huanyi Zhang (ORCID: https://orcid.org/0009-0004-4395-0425)
- Yan Liu (ORCID: https://orcid.org/0000-0002-2743-455X)
- Xinyu Zhang (ORCID: https://orcid.org/0000-0001-8154-9334)
- Peng Li (ORCID: https://orcid.org/0000-0003-2030-1807)
- Guihua Jiang (ORCID: https://orcid.org/0000-0002-8344-7670)
- Zongwei Lin
- Hongyan Dai (ORCID: https://orcid.org/0000-0001-6088-9532)
- Fenglei Zhang (ORCID: https://orcid.org/0000-0002-3217-9039)
- Dongxia Zhang
- Zhong Lin
- Tao Zhang (ORCID: https://orcid.org/0000-0002-3151-1642)
Institutions
- Qingdao University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wenzhou Medical University (CN)
- Yuhuangding Hospital (CN)
- Boxing People's Hospital (CN)
- Qingdao Municipal Hospital (CN)
- Xintai People's Hospital (CN)
- Ministry of Education (BD)
- Taian City Central Hospital (CN)
- Dongyang People's Hospital (CN)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1002/ehf2.15065
- Citations
- 6
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- Shandong University