Time-Dependent Potentiation of the PERK Branch of UPR by GPR68 Offers Protection in Brain Ischemia
These data demonstrate that GPR68 potentiation leads to neuroprotection, at least in part, through enhancing PERK-eIF2α activation in ischemic tissue but has little impact on healthy tissue.
Authors
- Wenyan Sun (ORCID: https://orcid.org/0000-0002-3186-5002)
- Guokun Zhou (ORCID: https://orcid.org/0000-0002-5755-507X)
- Xiang‐ming Zha (ORCID: https://orcid.org/0000-0001-9490-2731)
- Sarun Jonchhe
- Virendra Tiwari (ORCID: https://orcid.org/0000-0002-5637-1076)
- Grace Davis
Institutions
- Tulane University (US)
- Nantong University (CN)
- University of Missouri–Kansas City (US)
- University of South Alabama (US)
Publication Details
- Journal
- Stroke
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1161/strokeaha.124.048163
- Citations
- 2
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.47