Ischemia–reperfusion injury after spinal cord decompressive surgery—An in vivo rat model
This model is deemed suitable for analyzing the underlying mechanism of SCII following decompressive cervical laminectomy, as we posit that the obtained results are comparable to the clinical progression of degenerative cervical myelopathy (DCM) post-decompression and exhibit analogous neurological alterations. Notably, this model revealed ischemic reperfusion in the spinal cord after decompression, concomitant with oxidative damage, which plausibly underlies the neurological deterioration observed after decompression.
Authors
- Pengren Luo (ORCID: https://orcid.org/0009-0001-8146-1954)
- Liguo Zhu (ORCID: https://orcid.org/0000-0003-2593-7978)
- Bowen Yang (ORCID: https://orcid.org/0000-0002-6305-5565)
- Xiaokuan Qin (ORCID: https://orcid.org/0000-0002-6993-1247)
- B. Y. Zhang
- Bo Xu (ORCID: https://orcid.org/0000-0002-3666-8905)
- He Yin (ORCID: https://orcid.org/0000-0001-8194-3542)
- Dian Zhang (ORCID: https://orcid.org/0000-0002-0696-2855)
- Zhefeng Jin
- Xin Chen (ORCID: https://orcid.org/0000-0002-5579-0447)
- Guo-Liang Ma
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wangjing Hospital of China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1002/ame2.12485
- Citations
- 4
- Primary Topic
- Cervical and Thoracic Myelopathy
- Type
- article
- Field-Weighted Citation Impact
- 2.29