Repurposing of a library for high-content screening of inhibitors against Echinococcus granulosus
Through the development of a novel HTS assay and by repurposing libraries, we identified omaveloxolone and niclosamide as potent inhibitors against E. granulosus. These compounds show promise as potential anti-echinococcal drugs, and our strategic approach has the potential to promote drug discovery for parasitic infections.
Authors
- Jun Li (ORCID: https://orcid.org/0000-0002-3126-3271)
- Jinzhi Wu
- Xiao‐Ben Pan (ORCID: https://orcid.org/0000-0002-7795-8159)
- Wenjing Qi (ORCID: https://orcid.org/0000-0002-9287-5837)
- Yao Zhang
- Mingzhi Yan (ORCID: https://orcid.org/0009-0007-0122-7433)
- Gaofei Lv
- Wenbao Zhang (ORCID: https://orcid.org/0000-0002-3110-1600)
- C.F. Chan
- Weinan Zheng
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Drug Discovery Laboratory (Norway) (NO)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1186/s13071-024-06456-6
- Citations
- 1
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Bill and Melinda Gates Foundation
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Tsinghua University