Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

Recent Ebola outbreaks underscore the importance of continuous prevention and disease control efforts. Authorized vaccines include Merck's Ervebo (rVSV-ZEBOV) and Johnson & Johnson's two-dose combination (Ad26.ZEBOV/MVA-BN-Filo). Here, in a five-year follow-up of the PREVAC randomized trial (NCT02876328), we report the results of the immunology ancillary study of the trial. The primary endpoint is to evaluate long-term memory T-cell responses induced by three vaccine regimens: Ad26-MVA, rVSV, and rVSV-booster. Polyfunctional EBOV-specific CD4<sup>+</sup> T-cell responses increase after Ad26 priming and are further boosted by MVA, whereas minimal responses are observed in the rVSV groups, declining after one year. In-vitro expansion for eight days show sustained EBOV-specific T-cell responses for up to 60 months post-prime vaccination with both Ad26-MVA and rVSV, with no decline. Cytokine production analysis identify shared biomarkers between the Ad26-MVA and rVSV groups. In secondary endpoint, we observed an elevation of pro-inflammatory cytokines at Day 7 in the rVSV group. Finally, we establish a correlation between EBOV-specific T-cell responses and anti-EBOV IgG responses. Our findings can guide booster vaccination recommendations and help identify populations likely to benefit from revaccination.

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Publication Details

Journal
Nature Communications
Published
2024-09-03
DOI
https://doi.org/10.1038/s41467-024-51453-z
Citations
13
Primary Topic
Viral Infections and Outbreaks Research
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article
Field-Weighted Citation Impact
5.06

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article

Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

Benetta C. Andrews, Natasha Howard, Papa Ndiaga Cissé, Fatoumata Diallo et al.
13 citations
Nature Communications
Viral Infections and Outbreaks Research
5.06
article

Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases

Benetta C. Andrews, Natasha Howard, Papa Ndiaga Cissé, Fatoumata Diallo, Kelly Cahill, Éric D’Ortenzio, David Ishola, Augustin Augier, Bockarie Koroma, Aurélie Wiedemann, Moses Massaquoi, Dickens Kowuor, Alain DuChêne, Yazdan Yazdanpanah, Nelson Dozier, Bruce Thompson, Aminata Bagayoko, Hilary Whitworth, Rita Lukoo Ndamenyaa, Robert Akpata, Babajide Keshinro, John McCullough, Teedoh Beyslow, Sibiry Samake, Beth Baseler, Richard Kojan, Julia Lysander, Tijili Tyee, Barbara Cagniard, Francois Chambelin, Soumaya Mohamed, Amy Falk Russell, David Vallée, Ydrissa Sow, Steven Mazur, Michael J. Stirratt, Maxime Schvartz, Melvin Johnson, Brian Köhn, Courtney Lambeth, Benjamin Hamzé, Yusupha Njie, Bolarinde Lawal, Melissa E. Hughes, Natasha Dubois Cauwelaert, Cynthia Robinson, Shuǐqìng Yú, Yvonne Jato, Édouard Lhomme, Tienhan Sandrine Dabakuyo‐Yonli, Bode Shobayo, Moses Badio, Laura Richert, Katherine Cone, Jeroen N. Stoop, Rachael Bonawitz, Blandine Binachon, J.W. Tierney, Micki Nelson, Waly Diouf, Jenny Hendriks, Maarten Leyssen, Rodolphe Thiébaut, Elisabeth Higgs, Philip Sahr, Florence Chung, Mary Smolskis, Boris Lacarra, Lamin Molecule Bangura, Tyler M. Brady, Ibrahim Sanogo, Page Crew, Julia García Gozalbes, Laure Masson, Claire Bauduin, Patricia Boison, Julie Blie, Pauline Michavila, Andrew Wen-Tseng Lee, Hélène Espérou, Nadeeka Randunu, Solange Lancrey-javal, Irina Maljkovic Berry, Lawrence Fakoli, Bionca Davis, Karen Slater, Guillaume Thaurignac, Harrison Gichini, Claire Lévy‐Marchal, Samba Diop, Trudi Hilton, Lindsay Marron, Myriam Kanté, Séverine Ciancia, Siew Pin Chai, Pauline Akoo, Delphine Yamadjako, Abdoul Habib Béavogui, Daniel Tindanbil, Ayouba Diarra, Daniela Fusco, Chelsea McLean, Janie Liang, Nathalie Swales, Micheal Piziali, Yíngyún Caì, Judith Katoudi, Sara Albert, Jennifer Cash, Viki Bockstal, Eline Dekeyster, Vinh‐Kim Nguyen, Auguste Gaddah, Macaya Douoguih, Mohamed Samai, Michael Duvenhage, Laurie Connor, Laurie Lambert, Alexandre Quach, Kokulo Franklin, Alexandre Lima de Araújo Ribeiro, Djénéba Dabitao, Sandrine Couffin-Cardiergues, Jayanthi Wolf, Nathan Peiffer‐Smadja, Inmaculada Ortega‐Pérez, Mamoudou Kodio, Laurie Doepel, Aissata Abdoulaye Camara, Jemee Tegli, Mosoka Fallah, Luisa Enria, Boni Maxime Ale, Bonnie Dighero-Kemp, Birgit Grund, Djélikan Siaka Conde, Elena Postnikova, Maima Gray, Jamila Aboulhab, Barthalomew Wilson, Seydou Doumbia, Calvin Proffitt, Abby Balde, Gregory Kocher, Billy Muyisa Sivahera, Jonathan Marchand, Fadima Cheick Haidara, Sani Sayadi, Aboubacar Kaba, Julius Teahton, Renaud Vatrinet, Shelly Simpson, Negin Atri, Nicholas E. 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Phillips, Matthew Kirchoff, Fatou Secka, Uma Onwuchekwa, Annabelle Lefevre, Noémie Mercier, Abdoulaye Touré, Ali Bauder, Alseny Camara, Matthew Onorato, James Pettitt, Stéphany Pong, Sienneh Tamba, Cecelia Wesseh, Antoine Campagne, Daniela Manno, Sinead Quigley, Alie Wurie, Lucy Chung, Greg Grandits, Yeya Sadio Sarro, Oualy Diawara, Liane Kwast, Emily Snowden, Cynthia Osborne, Deborah Watson-Jones, Mickael Hneino, Tracey-Ann Höeltermannl, Brent Killinger, Katherine McFadyen, Safaa Ben-Farhat, Nicolas Bernaud, Neirade Biai, Alexandre Cantan
article en
13 citations

Abstract

Recent Ebola outbreaks underscore the importance of continuous prevention and disease control efforts. Authorized vaccines include Merck's Ervebo (rVSV-ZEBOV) and Johnson & Johnson's two-dose combination (Ad26.ZEBOV/MVA-BN-Filo). Here, in a five-year follow-up of the PREVAC randomized trial (NCT02876328), we report the results of the immunology ancillary study of the trial. The primary endpoint is to evaluate long-term memory T-cell responses induced by three vaccine regimens: Ad26-MVA, rVSV, and rVSV-booster. Polyfunctional EBOV-specific CD4<sup>+</sup> T-cell responses increase after Ad26 priming and are further boosted by MVA, whereas minimal responses are observed in the rVSV groups, declining after one year. In-vitro expansion for eight days show sustained EBOV-specific T-cell responses for up to 60 months post-prime vaccination with both Ad26-MVA and rVSV, with no decline. Cytokine production analysis identify shared biomarkers between the Ad26-MVA and rVSV groups. In secondary endpoint, we observed an elevation of pro-inflammatory cytokines at Day 7 in the rVSV group. Finally, we establish a correlation between EBOV-specific T-cell responses and anti-EBOV IgG responses. Our findings can guide booster vaccination recommendations and help identify populations likely to benefit from revaccination.

Nature CommunicationsVol. 15(1)
Université Claude Bernard Lyon 1 (FR), Leidos (United States) (US), University of Maryland, Baltimore (US), Merck & Co., Inc., Rahway, NJ, USA (United States) (US), National Institutes of Health (US), University of Minnesota (US), Institut national de recherche en sciences et technologies du numérique (FR), Université de Bordeaux (FR), Inserm (FR), University of Sierra Leone (SL), Université Paris-Est Créteil (FR), Université de Montpellier (FR), Centre Hospitalier Universitaire de Bordeaux (FR), Centre Pour le Développement des Vaccins-Mali (ML), London School of Hygiene & Tropical Medicine (GB), Alliance for International Medical Action (SN), Assistance Publique – Hôpitaux de Paris (FR), Planned Parenthood Association of Liberia (LR), Bordeaux Population Health (FR), Université des Sciences, des Techniques et des Technologies de Bamako (ML), Agence Nationale de Recherches sur le Sida et les Hépatites Virales (FR), Institut de Recherche Vaccinale (FR), Institut Bergonié (FR), National Institute of Allergy and Infectious Diseases (US), Hôpital Bichat-Claude-Bernard (FR), Institut National de Santé Publique (GN), Janssen (Netherlands) (NL), Hôpital Albert-Chenevier (FR), National Institute of Mental Health (US), Institut Mondor de Recherche Biomédicale (FR), Institut de Recherche pour le Développement (FR), Centre d'Investigation Clinique Plurithématique de Bordeaux, Leidos Biomedical Research Inc. (United States), Université de Montréal (CA), Cheikh Anta Diop University (SN)
U.S. Department of Health and Human Services, London School of Hygiene and Tropical Medicine, Frederick National Laboratory for Cancer Research, European Federation of Pharmaceutical Industries and Associations, European Commission, Institut National de la Santé et de la Recherche Médicale, Bavarian Nordic, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, European and Developing Countries Clinical Trials Partnership
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