Impact of adequate empirical combination therapy on mortality in septic shock due to <i>Pseudomonas aeruginosa</i> bloodstream infections: a multicentre retrospective cohort study
AECT may be associated with reduced mortality compared to monotherapy in septic shock patients due to P. aeruginosa BSI. However, the administration of definitive adequate monotherapy or combination therapy yields similar outcomes, suggesting that once susceptibility is documented, switching to a single active in vitro drug is safe and feasible. Further studies are recommended to validate these findings.
Authors
- Vincenzo Scaglione (ORCID: https://orcid.org/0000-0002-2911-2255)
- Eleonora Taddei (ORCID: https://orcid.org/0000-0002-5983-4291)
- Bianca Pari
- Małgorzata Mikulska (ORCID: https://orcid.org/0000-0002-5535-4602)
- Nicholas Geremia (ORCID: https://orcid.org/0000-0001-7988-5419)
- Renato Pascale (ORCID: https://orcid.org/0000-0003-2687-4235)
- Veronica Vassia (ORCID: https://orcid.org/0000-0002-7097-0710)
- Silvia Corcione (ORCID: https://orcid.org/0000-0003-2949-4297)
- Marco Muccio (ORCID: https://orcid.org/0000-0003-1559-7113)
- Matteo Bassetti (ORCID: https://orcid.org/0000-0002-0145-9740)
- Davide Fiore Bavaro (ORCID: https://orcid.org/0000-0002-4833-7118)
- Pierluigi Viale (ORCID: https://orcid.org/0000-0003-1264-0008)
- Simone Mornese Pinna (ORCID: https://orcid.org/0000-0002-0148-1075)
- Flavio Sangiorgi (ORCID: https://orcid.org/0009-0009-7267-8068)
- Maddalena Giannella (ORCID: https://orcid.org/0000-0001-8273-7601)
- Francesco Giuseppe De Rosa (ORCID: https://orcid.org/0000-0001-8338-0130)
- Daniele Roberto Giacobbe (ORCID: https://orcid.org/0000-0003-2385-1759)
- Antonio Vena (ORCID: https://orcid.org/0000-0002-0697-3992)
- Marco Merli (ORCID: https://orcid.org/0000-0001-5081-8669)
- Francesca Giovannenze (ORCID: https://orcid.org/0000-0002-6972-6470)
- Michele Bartoletti (ORCID: https://orcid.org/0000-0002-1099-3283)
- Michela Schenone
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Tufts University (US)
- Humanitas University (IT)
- University of Padua (IT)
- Agostino Gemelli University Polyclinic (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Ospedale Civile Di Ivrea (IT)
- A. O. Ordine Mauriziano di Torino (IT)
- Ospedale dell' Angelo (IT)
- Ospedale Policlinico San Martino (IT)
- University of the Sacred Heart (JP)
- Hospital for Tropical Diseases (VN)
- IRCCS Humanitas Research Hospital (IT)
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
- University of Genoa (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1093/jac/dkae296
- Citations
- 16
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.19
Funders
- Pfizer