Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of <i>bla</i> KPC-carbapenemase-producing Enterobacterales in a hospital setting
We identified substantial and diverse KPC-E colonization of wastewater sites and patients in this hospital setting. Reservoir and niche-specific factors (e.g. microbial interactions, selection pressures), and different strains and mobile genetic elements likely affect transmission dynamics. This should be considered in surveillance and control strategies.
Authors
- Neil Woodford (ORCID: https://orcid.org/0000-0003-1396-8953)
- Mark Neilson
- Michel Doumith (ORCID: https://orcid.org/0000-0002-8004-0314)
- Ryan George (ORCID: https://orcid.org/0000-0001-5912-2879)
- Zoie Aiken
- Sarah Neilson
- Tünde Pető (ORCID: https://orcid.org/0000-0001-6265-0381)
- Paul Cleary (ORCID: https://orcid.org/0000-0001-9335-5422)
- Andrew Mumford (ORCID: https://orcid.org/0000-0002-5523-511X)
- Tim Peto (ORCID: https://orcid.org/0000-0003-3477-8307)
- Nicole Stoesser (ORCID: https://orcid.org/0000-0002-4508-7969)
- Nicola De Maio (ORCID: https://orcid.org/0000-0002-1776-8564)
- Aiysha Ali
- Andrew Walker (ORCID: https://orcid.org/0000-0003-4715-4325)
- Julie Cawthorne
- Vicky Watts
- Cheryl Lenney
- Samuel Lipworth (ORCID: https://orcid.org/0000-0001-5872-9214)
- Jay Turner-Gardner
- Amy J. Mathers (ORCID: https://orcid.org/0000-0002-3533-6351)
- A Sarah Walker (ORCID: https://orcid.org/0000-0003-0421-9264)
- Malcolm Guiver
- Rachel Jones
- Matthew J. Ellington (ORCID: https://orcid.org/0000-0002-0656-3360)
- William Welfare (ORCID: https://orcid.org/0000-0002-8304-1048)
- Jeremy Swann (ORCID: https://orcid.org/0000-0002-1475-8248)
- David W. Eyre (ORCID: https://orcid.org/0000-0001-5095-6367)
- Anna C. Seale (ORCID: https://orcid.org/0000-0002-0129-3146)
- T. Phuong Quan (ORCID: https://orcid.org/0000-0001-8566-1817)
- Katie L. Hopkins (ORCID: https://orcid.org/0000-0001-7279-5322)
- Hang Phan (ORCID: https://orcid.org/0000-0001-9586-081X)
- Valérie Decraene (ORCID: https://orcid.org/0000-0001-6936-7263)
- Ashley McEwan (ORCID: https://orcid.org/0000-0002-0169-6594)
- Mark Regan (ORCID: https://orcid.org/0000-0003-3728-971X)
- Alison Vaughan (ORCID: https://orcid.org/0000-0003-0493-6255)
- David Wyllie (ORCID: https://orcid.org/0000-0002-9155-6228)
- Oluwafemi Akinremi
- Derrick W. Crook (ORCID: https://orcid.org/0000-0002-0590-2850)
- Robert L. Hill (ORCID: https://orcid.org/0009-0001-2747-3997)
- Ginny Moore (ORCID: https://orcid.org/0000-0001-6969-3528)
- Jimmy Walker
- Andrew Dodgson
- John Grimshaw
Institutions
- European Bioinformatics Institute (GB)
- University of Liverpool (GB)
- John Radcliffe Hospital (GB)
- Public Health England (GB)
- University of Warwick (GB)
- University of Oxford (GB)
- Manchester University NHS Foundation Trust (GB)
- Oxford Biomedical Research (US)
- Charlottesville Medical Research (US)
- Bioinformatics Institute (RU)
- Oxford BioMedica (United Kingdom) (GB)
- Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool (GB)
- University of Southampton (GB)
- University of Virginia (US)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2024-08-15
- DOI
- https://doi.org/10.1093/jacamr/dlae140
- Citations
- 9
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Wellcome Trust
- National Institute for Health and Care Research