Dietary protein defends lean mass and maintains the metabolic benefits of glucagon receptor agonism in mice
Glucagon-mediated energy expenditure and weight loss may be mechanistically coupled to hypoaminocidemia and lean mass loss. However, our data suggest that glucagon can treat MAFLD at doses which allow full defence of lean mass given sufficient dietary protein intake. Therefore, proportionate glucagon therapy may be safe and effective in targeting hepatocytes and improving in glycaemia and liver fat.
Authors
- Dirk Dormann (ORCID: https://orcid.org/0000-0001-6309-7522)
- David Carling (ORCID: https://orcid.org/0000-0002-2316-1830)
- Tatiana Lopes (ORCID: https://orcid.org/0009-0000-1310-5483)
- Tricia Tan (ORCID: https://orcid.org/0000-0001-5873-3432)
- Kevin G. Murphy (ORCID: https://orcid.org/0000-0002-3417-0310)
- David C. D. Hope (ORCID: https://orcid.org/0000-0002-0240-0687)
- Bryn M. Owen (ORCID: https://orcid.org/0000-0001-5296-7553)
- Alessandro Sardini (ORCID: https://orcid.org/0000-0002-4915-3687)
- José M. Ramos Pittol (ORCID: https://orcid.org/0000-0003-3753-5394)
- Jed Valentiner Shrewsbury (ORCID: https://orcid.org/0000-0003-0604-6467)
- Gavin A. Bewick (ORCID: https://orcid.org/0000-0002-4335-8403)
- Iona Davies
- James Minnion (ORCID: https://orcid.org/0000-0002-4987-1224)
- Zijing Zhou
- Stephen R. Bloom
- Anna Curtis
Institutions
- King's College London (GB)
- Universität Innsbruck (AT)
- NIHR Imperial Biomedical Research Centre (GB)
- MRC London Institute of Medical Sciences (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1016/j.molmet.2024.102024
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Wellcome Trust
- District of Columbia Department of Health
- National Institute for Health and Care Research
- Royal Society
- Diabetes UK
- Tiroler Wissenschaftsförderung
- Standortagentur Tirol
- Medical Research Council
- Biotechnology and Biological Sciences Research Council