NNMT overexpression is an adverse prognostic factor in uterine leiomyosarcoma
NNMT can aid in the preoperative differentiation of uLMS and uLM. The consequences of NNMT overexpression, such as the activation and inactivation of oncoproteins and tumor suppressor proteins, respectively, as well as the enrichment of the cancer stem cell population, overlap with the major mechanisms responsible for poor prognosis in mesenchymal tumors. NNMT may be investigated further in the context of antitumor treatment in patients with mesenchymal malignancies.
Authors
- Serra Akar (ORCID: https://orcid.org/0000-0002-0466-140X)
- Zeliha Esin Çelik (ORCID: https://orcid.org/0000-0002-3220-7845)
- Nazmiye Dinçer (ORCID: https://orcid.org/0000-0001-6478-7808)
- Osman Türkmen (ORCID: https://orcid.org/0000-0002-1470-7731)
- Kamil Hakan Müftüoğlu (ORCID: https://orcid.org/0000-0003-4069-0002)
Institutions
- Selçuk University (TR)
- Ankara University (TR)
- Bilkent University (TR)
- University of Health Science (KH)
- Memorial Ankara Hospital (TR)
- Başkent University Hospital (TR)
- Sağlık Bilimleri Üniversitesi (TR)
Publication Details
- Journal
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Published
- 2024-08-23
- DOI
- https://doi.org/10.55730/1300-0144.5852
- Primary Topic
- Uterine Myomas and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Selçuk Üniversitesi