Knockdown of HSPA13 Inhibits TGFβ1-Induced Epithelial-Mesenchymal Transition of RPE by Suppressing the PI3K/Akt Signaling Pathway
Our study revealed the involvement of HSPA13 in PVR development, as well as in TGFβ1-induced EMT of RPE through the PI3K/Akt signaling pathway. Targeting HSPA13-related pathways involved in regulating EMT in RPE cells could serve as a novel therapeutic approach for patients with PVR.
Authors
- Qingjian Ou (ORCID: https://orcid.org/0000-0002-6881-8680)
- Haibin Tian (ORCID: https://orcid.org/0000-0002-3557-0965)
- Caixia Jin
- Jie Xu (ORCID: https://orcid.org/0000-0002-5059-3671)
- Furong Gao (ORCID: https://orcid.org/0000-0003-0394-2557)
- Lilin Zhu (ORCID: https://orcid.org/0009-0001-7912-0974)
- Jiao Li (ORCID: https://orcid.org/0000-0001-9446-5076)
- Jia Song (ORCID: https://orcid.org/0000-0001-6039-6340)
- Jingying Xu (ORCID: https://orcid.org/0000-0002-1294-9040)
- Lixia Lü (ORCID: https://orcid.org/0000-0003-0268-4656)
- Guo-Tong Xu
- Mengwen Li (ORCID: https://orcid.org/0000-0002-6841-3843)
- Wei Xu (ORCID: https://orcid.org/0009-0006-3042-608X)
- Juan Wang (ORCID: https://orcid.org/0000-0002-5023-5081)
Institutions
- Tongji University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1167/iovs.65.11.1
- Citations
- 5
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Fundamental Research Funds for the Central Universities