Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease Codes in Patient Records
LLMs are a useful tool for the detection of irAEs, outperforming ICD codes in sensitivity and adjudication in efficiency.
Authors
- Azin Ghamari (ORCID: https://orcid.org/0000-0003-4688-8124)
- Julius C. Heemelaar (ORCID: https://orcid.org/0000-0001-6892-5227)
- Benjamin D. Medoff (ORCID: https://orcid.org/0000-0002-2558-0449)
- Ryan J. Sullivan (ORCID: https://orcid.org/0000-0001-5344-6645)
- Virginia H. Sun (ORCID: https://orcid.org/0000-0003-1387-2994)
- Steven Michael Blum (ORCID: https://orcid.org/0000-0001-6030-7192)
- Hannah Gilman
- Ayo Samuel Falade (ORCID: https://orcid.org/0000-0001-9201-6998)
- Shilpa Grover (ORCID: https://orcid.org/0000-0001-6268-6843)
- Leyre Zubiri (ORCID: https://orcid.org/0000-0003-4226-7443)
- Molly Thomas (ORCID: https://orcid.org/0000-0002-1393-6559)
- Kerry L. Reynolds (ORCID: https://orcid.org/0000-0002-7793-654X)
- Michael Dougan (ORCID: https://orcid.org/0000-0001-9266-2009)
- Jor Sam Ho
- Alexandra–Chloé Villani (ORCID: https://orcid.org/0000-0001-7461-0408)
- Meghan E. Sise (ORCID: https://orcid.org/0000-0002-4327-9713)
- Giselle Alexandra Suero‐Abreu (ORCID: https://orcid.org/0000-0002-4274-2761)
- Osama Abu-Shawer
- Kelley Grealish
- Kenneth L. Kehl (ORCID: https://orcid.org/0000-0001-5339-9797)
- Nora Hathaway (ORCID: https://orcid.org/0009-0009-2428-9367)
- Vineet K. Raghu (ORCID: https://orcid.org/0000-0003-3524-3945)
- Ibrahim Hadžić (ORCID: https://orcid.org/0000-0002-8397-5940)
- Daniel A. Zlotoff (ORCID: https://orcid.org/0000-0001-9007-7295)
- Nicole R. LeBoeuf (ORCID: https://orcid.org/0000-0002-8264-834X)
- Meghan J. Mooradian (ORCID: https://orcid.org/0000-0002-8289-8015)
- Prabhsimranjot Singh (ORCID: https://orcid.org/0000-0001-6791-5123)
- Tomas G. Neilan (ORCID: https://orcid.org/0000-0002-1513-8833)
- Chia‐Yun Wu
- Jessica Y. Wu
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- Intel (United States) (US)
- Harvard University (US)
- Oregon Health & Science University (US)
- Leiden University Medical Center (NL)
- Salem Hospital (US)
- Maastricht University (NL)
- Massachusetts General Hospital (US)
- Far Eastern Memorial Hospital (TW)
- Dana-Farber Cancer Institute (US)
- Center for Cancer Research (US)
- Mass General Brigham (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1200/jco.24.00326
- Citations
- 24
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 9.34
Funders
- Eli Lilly and Company
- Massachusetts General Hospital
- Mallinckrodt Pharmaceuticals
- Foghorn Therapeutics
- Genentech