Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19

We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1. Subjects recorded PCR or antigen tests and the symptoms of COVID-19 twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines were measured. The rates of COVID-19 infection were 50.5% in the vitamin D2 group and 52.4% in the non-intervention group (P = 0.785). There was no difference in the COVID-19 symptoms between the two groups. The mean 25(OH)D level significantly increased from 14.1 to 31.1 ng/mL after administration (P < 0.001). The difference between the two groups was not significant for the concentrations of CRP, C1q and inflammatory cytokines on the thirtieth day of the trial. According to the second level of vitamin D, there was a 14.3% difference in positive infection rates between the vitamin D adequate (> 30 ng/mL) and deficient groups (< 20 ng/mL). Adequate vitamin D had a tendency to prevent COVID-19.Trial registration: ClinicalTrials.gov NCT05673980, dated: 12/2022.

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Publication Details

Journal
Scientific Reports
Published
2024-09-03
DOI
https://doi.org/10.1038/s41598-024-66267-8
Citations
3
Primary Topic
Vitamin D Research Studies
Type
article
Field-Weighted Citation Impact
1.27

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article

Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19

Lixiang Xue, Yanfang Jiang, Yunjing Hu, Chunli Song et al.
3 citations
Scientific Reports
Vitamin D Research Studies
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article

Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19

Lixiang Xue, Yanfang Jiang, Yunjing Hu, Chunli Song, Yang Lv, Yuping Yang, Liyuan Tao, Huan Wang, Xiaoxiao Wang, Haiyan Li, Na Liu, Yanfang Li, Hao Liu, Lijuan Yang, Tiancheng Wang, Baohua Li, Dongyang Liu, Liyan Cui, Yahong Chen, Fuchun Zhang, Yuling Gao, Jie Huang, Wanqiong Yuan
article en
3 citations

Abstract

We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1. Subjects recorded PCR or antigen tests and the symptoms of COVID-19 twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines were measured. The rates of COVID-19 infection were 50.5% in the vitamin D2 group and 52.4% in the non-intervention group (P = 0.785). There was no difference in the COVID-19 symptoms between the two groups. The mean 25(OH)D level significantly increased from 14.1 to 31.1 ng/mL after administration (P < 0.001). The difference between the two groups was not significant for the concentrations of CRP, C1q and inflammatory cytokines on the thirtieth day of the trial. According to the second level of vitamin D, there was a 14.3% difference in positive infection rates between the vitamin D adequate (> 30 ng/mL) and deficient groups (< 20 ng/mL). Adequate vitamin D had a tendency to prevent COVID-19.Trial registration: ClinicalTrials.gov NCT05673980, dated: 12/2022.

Scientific ReportsVol. 14(1)
Harvard University (US), Peking University (CN), Peking University Third Hospital (CN), Beijing Haidian Hospital (CN)
National Natural Science Foundation of China, Peking University, Peking University Third Hospital, National Key Research and Development Program of China
Zero hunger
Openalex Percentile: Top 20%
Vitamin D Research Studies
1.27
DOIOpen Access PDFOpenAlex
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