Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study
In this porcine model of VILI, we found a topographical correlation between lung strain and [<sup>68</sup>Ga]Ga-DOTA-TATE uptake at voxel level, suggesting that mechanical alteration and specific activation of inflammatory cells are strongly linked in VILI. This study represents the first voxel-by-voxel examination of this relationship in a multi-modal imaging analysis.
Authors
- Emmi Puuvuori (ORCID: https://orcid.org/0000-0001-8501-218X)
- Paolo Pelosi (ORCID: https://orcid.org/0000-0001-5055-3023)
- Olof Eriksson (ORCID: https://orcid.org/0000-0002-2515-8790)
- Elena Chiodaroli
- Francesco Liggieri
- Gaetano Perchiazzi (ORCID: https://orcid.org/0000-0001-6834-6399)
- Gunnar Antoni (ORCID: https://orcid.org/0000-0002-1525-5255)
- Lorenzo Ball (ORCID: https://orcid.org/0000-0002-3876-4730)
- Davide Chiumello (ORCID: https://orcid.org/0000-0001-9260-3930)
- Jonathan Sigfridsson (ORCID: https://orcid.org/0000-0001-8382-3624)
- Irina Velikyan (ORCID: https://orcid.org/0000-0002-3732-8857)
- Sebastiano Stramaglia (ORCID: https://orcid.org/0000-0002-5873-8564)
- Mariangela Pellegrini (ORCID: https://orcid.org/0000-0001-5668-7399)
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Istituto Nazionale di Fisica Nucleare (IT)
- University of Milan (IT)
- Science for Life Laboratory (SE)
- Ospedale San Paolo (IT)
- Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
- University of Bari Aldo Moro (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1186/s40635-024-00663-2
- Citations
- 5
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Svenska Sällskapet för Medicinsk Forskning
- Hjärt-Lungfonden
- Vetenskapsrådet
- Barndiabetesfonden
- Akademiska Sjukhuset
- Stiftelsen Familjen Ernfors Fond
- Uppsala Universitet
- Svenska Läkaresällskapet
- P. O. Zetterlings stiftelse
- Diabetesfonden