Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD
Our data suggest that the positive effect of Nup153 on neurogenesis is based on a complex regulatory network orchestrated by Nup153 and that this protein is a valuable disease target.
Authors
- Elena Paccosi (ORCID: https://orcid.org/0000-0001-5995-8692)
- Marcello D’Ascenzo (ORCID: https://orcid.org/0000-0003-0073-412X)
- Federica Conte (ORCID: https://orcid.org/0000-0003-0427-1476)
- Lucia Leone (ORCID: https://orcid.org/0000-0002-0695-7212)
- Claudio Grassi (ORCID: https://orcid.org/0000-0001-7253-1685)
- Giuseppe Aceto (ORCID: https://orcid.org/0000-0002-7530-6835)
- Claudia Colussi (ORCID: https://orcid.org/0000-0002-7727-8911)
- Cristian Ripoli (ORCID: https://orcid.org/0000-0002-5315-0163)
- Camillo Marra (ORCID: https://orcid.org/0000-0003-3994-4044)
- Raimondo Sollazzo (ORCID: https://orcid.org/0000-0002-6594-231X)
- Domenica Donatella Li Puma (ORCID: https://orcid.org/0000-0001-6729-6967)
- Maria Gabriella Vita (ORCID: https://orcid.org/0000-0002-6547-4990)
- Luca Nardella
- Marco Rinaudo (ORCID: https://orcid.org/0000-0002-6130-7335)
- Alessia Bertozzi (ORCID: https://orcid.org/0000-0003-1025-5034)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti (IT)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1186/s13287-024-03805-1
- Citations
- 1
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- Alzheimer's Association