CCL5 promotes the epithelial-mesenchymal transition of circulating tumor cells in renal cancer
In summary, CCL5 promoted EMT in renal cancer cells and CTCs through smad2/3, enhancing the malignant phenotype and facilitating lung metastasis. Mesenchymal-type CTC-related factors can construct a risk model for renal cancer patients, allowing personalized treatment based on metastatic risk prediction.
Authors
- Ni Guo
- Ziyan Wan
- Lingyu Guo (ORCID: https://orcid.org/0000-0002-4267-2302)
- Tie Chong (ORCID: https://orcid.org/0000-0002-2035-6544)
- Mei Gao (ORCID: https://orcid.org/0000-0001-8960-8749)
- Fangshi Xu (ORCID: https://orcid.org/0000-0002-2282-4743)
- Juanhua Tian
- Zhixin Huang (ORCID: https://orcid.org/0000-0002-8971-6421)
- Xueyi Liu (ORCID: https://orcid.org/0000-0002-6222-5825)
- Yibing Guan
- Guang Yang (ORCID: https://orcid.org/0000-0002-0012-3831)
Institutions
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-03
- DOI
- https://doi.org/10.1186/s12967-024-05297-2
- Citations
- 6
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Health Commission of Henan Province