Recent Trends in Chemistry and Biological Activity of Antipsychotics

Several novel antipsychotics have been outlined in this review. Different synthetic methods for the synthesis of promising antipsychotics have been summarized. There are different starting materials from which we can start to prepare the proposed antipsychotics. Also, the final nucleus of the proposed antipsychotics is different e.g. 8-azabicyclo[3.2.1]oct-3β-yl-amide 8a-w, 3-aminoethyl tetralones 19, 3-fluourobenzoyl-propionic acid 22, 6,7-dihydrobenzo[b]thiophen- 4(5H)-one derivative 26, 3,4-dihydronaphthalen-1(2H)-one derivative 30, Benzocycloalkanone derivative 36, 3-methyl-6,7-dihydrobenzo[d]isoxazol-4(5H)-one derivative 55, 1,5,6,7- tetrahydro-4H-indazol-4-one derivative 61, 2-methyl-1,5,6,7-tetrahydro-4H-benzo[d]imidazol-4- one derivative 66. Different antipsychotic activities of the prepared compounds are summarized.