Etomidate protects retinal ganglion cells from hydrogen peroxide-induced injury via Nrf2/HO-1 pathway
ET is a neuroprotective agent in primary cultured RGCs injured by H<sub>2</sub>O<sub>2</sub>. The effect of ET is dose-dependent with the greatest effect being at 10 µmol/L. ET plays an antioxidant role by inhibiting iNOS, up-regulating Nrf2/HO-1, decreasing the production of acrolein, and increasing the scavenge of acrolein.
Authors
- Fang Kuang (ORCID: https://orcid.org/0000-0003-0594-7773)
- Ming-Mei Wu
- Xuan Zhao
- Xinchao Zhang
- Si–Wei You
Institutions
- Northwest University (CN)
- Xi'an Honghui Hospital (CN)
- Xi'an Medical University (CN)
- Xi'an Jiaotong University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- International Journal of Ophthalmology
- Published
- 2024-08-20
- DOI
- https://doi.org/10.18240/ijo.2024.09.05
- Citations
- 2
- Primary Topic
- Drug-Induced Ocular Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 1.08
Funders
- Xi'an Medical University