Bilateral choroidal ganglioneuroma: a comprehensive analysis of vision decline in a 6-year-old boy

W e write to present a 6-year-old boy with bilateral choroidal ganglioneuroma (CG) by comprehensive multimodal imaging (MMI) in a duration of 6-year follow-up.To our knowledge, this is the first case report with elaborate data to delineate the natural history of visual function and MMI in a boy with rare bilateral CG, confirmed by choroid biopsy.In this report, we summarize the 6-year follow-up (2017-2023) of best corrected visual acuity (BCVA), axial length (AL) and the spherical equivalent (SE) and MMI progress [especially ophthalmoscope and optical coherence tomography (OCT)] to illustrate how eyeball, retina and choroid evolve under this circumstance.Since there is no effective treatment for CG, our data may pave the way for future therapeutic development.Ganglioneuromas are typically benign, slow-growing tumors arising from neural crest cells in the sympathetic nervous system, consisting of ganglion cells, Schwann cells, and fibrous tissue [1] .They have been reported in various locations, such as the orbit, vertebral spines, liver, and lung, but rarely occur in the choroid [2] .CG is an extremely rare tumor, commonly