Intra-individual variability in lipoprotein(a): the value of a repeat measure for reclassifying individuals at intermediate risk
Temporal-related changes in Lp(a) variability were present in many individuals. A repeat Lp(a) measure may allow more precise Lp(a)-specific cardiovascular risk prediction for individuals whose initial value is in the EAS-defined intermediate 'grey-zone' category. Lp(a) variability should be included in calculating the expected effect sizes in future clinical research studies targeting Lp(a).
Authors
- Tarek Harb (ORCID: https://orcid.org/0000-0002-2573-5260)
- Efthymios Ziogos (ORCID: https://orcid.org/0000-0002-5343-8714)
- Gary Gerstenblith (ORCID: https://orcid.org/0000-0001-6046-6812)
- Thorsten M. Leucker (ORCID: https://orcid.org/0000-0003-2569-6617)
- Roger S. Blumenthal (ORCID: https://orcid.org/0000-0003-1910-3168)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Hospital (US)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1093/ehjopen/oeae064
- Citations
- 29
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 16.61
Funders
- Vanderbilt University
- Vanderbilt University Medical Center
- National Institutes of Health