HBr/TMSO/HFIP Mediated Chemoselective Modifications of Pyrrolo[2,1‐<i>a</i>]Isoquinolines
Abstract The combination of HBr, TMSO (tetramethylene sulfoxide) and HFIP (hexafluoroisopropanol) has been utilized in the modification of pyrrolo[2,1‐ a ]isoquinoline derivatives through bromination, dimerization and sulfenylation respectively. In these processes, HBr serves as the source of bromine and TMSO acts as an oxidant. HFIP also plays an essential role for the oxidative dimerization. Chemoselectivity can be easily controlled by adjusting the parameters such as reaction time, ratio of reagents and the addition of nucleophile.
Authors
- Man Jiang (ORCID: https://orcid.org/0000-0002-3182-6863)
- Jing Zhou (ORCID: https://orcid.org/0000-0001-5074-2502)
Institutions
- Chongqing University of Arts and Sciences (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1002/ajoc.202400323
- Primary Topic
- Synthesis and Characterization of Pyrroles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chongqing University
- Chongqing Municipal Education Commission
- Chongqing University of Science and Technology