Association of PARP1 Expression Levels and Clinical Parameters in Different Leukemic Subtypes With BCR::ABL1 p190+ Translocation
Despite the lack of statistical correlation between the variables analyzed, the role of PARP1 in BCR::ABL1 leukemia cannot be ruled out, given the instability profile promoted by this translocation. Finally, further studies involving a larger sample of patients are needed, as well as investigations into other molecular pathways that may impact on the pathogenesis of different BCR::ABL1 leukemic subtypes.
Authors
- Maria Elisabete Amaral de Moraes (ORCID: https://orcid.org/0000-0002-6826-8930)
- Aline Damasceno Seabra (ORCID: https://orcid.org/0009-0009-0032-9459)
- Caroline Aquino Moreira-Nunes (ORCID: https://orcid.org/0000-0001-5845-3481)
- Rommel Mário Rodríguez Burbano (ORCID: https://orcid.org/0000-0002-4872-234X)
- Jean Breno Silveira da Silva (ORCID: https://orcid.org/0000-0002-0838-3195)
- André Salim Khayat
- Flávia Melo Cunha de Pinho Pessoa (ORCID: https://orcid.org/0000-0002-8432-4760)
- Fernando Augusto Rodrigues Mello Júnior
- Caio Bezerra Machado (ORCID: https://orcid.org/0000-0001-8918-9812)
- Deivide de Sousa Oliveira (ORCID: https://orcid.org/0000-0001-8630-3739)
- Manoel Odorico de Moraes (ORCID: https://orcid.org/0000-0003-3378-8722)
- Beatriz Maria Dias Nogueira (ORCID: https://orcid.org/0009-0009-0092-862X)
- RODRIGO MONTEIRO RIBEIRO
- Guilherme Passos de Morais (ORCID: https://orcid.org/0009-0008-8016-9274)
Institutions
- Universidade Federal do Ceará (BR)
- Amazon Research Foundation (BR)
- Unichristus (BR)
- Hospital Geral de Fortaleza (BR)
- Universidade Federal do Pará (BR)
Publication Details
- Journal
- Cancer Diagnosis & Prognosis
- Published
- 2024-09-01
- DOI
- https://doi.org/10.21873/cdp.10368
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico