Experimental Periodontitis Worsens Dopaminergic Neuronal Degeneration
This study provides original insights into the association between periodontitis and a neurodegenerative condition. The increased inflammatory pathway associated with both 6-OHDA-induced dopaminergic neuron lesion and periodontal inflammatory processes corroborates that the periodontitis-induced systemic inflammation may aggravate neuroinflammation in Parkinson's-like disease, potentially hastening disease progression.
Authors
- Jardel Francisco Mazzi‐Chaves (ORCID: https://orcid.org/0000-0002-9889-1790)
- Manoel Damião Sousa‐Neto (ORCID: https://orcid.org/0000-0002-7696-7600)
- Gabrielle Jacob (ORCID: https://orcid.org/0000-0002-5640-4587)
- Michel Reis Messora (ORCID: https://orcid.org/0000-0001-8485-9645)
- Flávia Aparecida Chaves Furlaneto (ORCID: https://orcid.org/0000-0002-8072-3983)
- Yara Loyanne de Almeida Silva Levi (ORCID: https://orcid.org/0000-0003-1566-5673)
- Glauce Crivelaro Nascimento (ORCID: https://orcid.org/0000-0001-5116-2200)
- Bruna Araujo Milan
- Raquel de Souza Franco Nassar
- Livia Rodrigues Antonieto
- Marcela Costa Ribeiro
- Elaine Aparecida Del Bel (ORCID: https://orcid.org/0000-0002-4158-7376)
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
Publication Details
- Journal
- Journal Of Clinical Periodontology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1111/jcpe.14065
- Citations
- 4
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.60
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico