Methionine deficiency inhibited pyroptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella): possibly via activating the ROS-AMPK-autophagy axis
MD promoted autophagy and apoptosis, but inhibited pyroptosis and necroptosis. MD inhibited pyroptosis may be related regarding the promotion of autophagy. MD activated AMPK by inducing ROS production which in turn promoted autophagy. These results could provide partial theoretical basis for the possible mechanisms of Met in ensuring the normal structure and function of animal organs. Furthermore, ferroptosis is closely related to redox states, it is worth investigating whether MD affects ferroptosis in hepatocytes.
Authors
- Yuanlin He (ORCID: https://orcid.org/0000-0001-7019-6756)
- Xiao‐Wan Jin
- Pei Wu (ORCID: https://orcid.org/0000-0002-1833-7555)
- Ruinan Zhang (ORCID: https://orcid.org/0009-0008-8374-2662)
- Yang Liu (ORCID: https://orcid.org/0000-0001-5892-7448)
- Xiaoqiu Zhou (ORCID: https://orcid.org/0000-0002-8210-3331)
- Lin Feng (ORCID: https://orcid.org/0009-0008-7721-226X)
- Hongmei Ren
- Wei‐Dan Jiang
Institutions
- Sichuan Agricultural University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s40104-024-01069-6
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.77