Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation
Our findings present a strategy for the multi-targeted degradation of Ikaros proteins and CK1α against hematological cancers, which may be expanded to additional targets and indications. This strategy may enhance efficacy treatment against multiple hematological cancers and solid tumors.
Authors
- Junhai Xiao
- Shiyang Sun
- Changkai Jia
- Pengyun Li (ORCID: https://orcid.org/0000-0003-1592-6554)
- Pengli Wei
- Qijie Ran
- Zhiyuan Zhao (ORCID: https://orcid.org/0000-0002-6962-1791)
- Xiaomei Zhuang
- Ting Wei (ORCID: https://orcid.org/0000-0001-9008-0339)
- Weijie Qin (ORCID: https://orcid.org/0000-0002-7633-9786)
- Zhiya Fan (ORCID: https://orcid.org/0000-0002-2168-2341)
- Qiyu Jiang (ORCID: https://orcid.org/0009-0000-6177-7647)
- Ning Yang (ORCID: https://orcid.org/0000-0001-5772-3320)
- Xiaotong Hu (ORCID: https://orcid.org/0000-0001-9068-743X)
- Zhibing Zheng (ORCID: https://orcid.org/0000-0001-9096-2008)
- Song Li (ORCID: https://orcid.org/0000-0002-1664-6290)
- Tingting Xu (ORCID: https://orcid.org/0000-0001-5524-035X)
- Xiaohong Qian
- Fan Feng (ORCID: https://orcid.org/0000-0001-6756-6293)
- Jian Yan (ORCID: https://orcid.org/0000-0003-0258-0697)
- Xu Cai (ORCID: https://orcid.org/0000-0001-5675-5638)
- Yaqiu Mao (ORCID: https://orcid.org/0009-0008-2913-2425)
- Tingting Yang (ORCID: https://orcid.org/0000-0002-6808-7590)
Institutions
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Central Hospital of Wuhan (CN)
- Beijing Proteome Research Center (CN)
- Wuhan General Hospital of Guangzhou (CN)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2024-09-02
- DOI
- https://doi.org/10.1186/s13045-024-01592-z
- Citations
- 20
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China