Correlation between glymphatic dysfunction and cranial defect in severe traumatic brain injury: a retrospective case-control study based on a diffusion tensor image analysis along the perivascular space (DTI-ALPS) investigation
The non-invasive DTI-ALPS technique revealed significantly reduced ALPS index values during the recovery phase of sTBI, indicating persistent impairment in glymphatic system function. A significant negative correlation was found between the ALPS index value of the craniectomy side and the size of the cranial defect. These findings suggest that the ALPS index may serve as a valuable prognostic factor in the recovery phase of sTBI.
Authors
- Jiacheng Liu (ORCID: https://orcid.org/0000-0002-7786-9957)
- Yong Guo (ORCID: https://orcid.org/0000-0001-6485-7925)
- Jinfang Liu (ORCID: https://orcid.org/0000-0001-6986-1173)
- Zhongyi Sun (ORCID: https://orcid.org/0009-0003-7249-5428)
- Lin Wu (ORCID: https://orcid.org/0000-0001-7449-9922)
Institutions
- Central South University (CN)
- Wayne State University (US)
- Henan Provincial People's Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Quantitative Imaging in Medicine and Surgery
- Published
- 2024-09-01
- DOI
- https://doi.org/10.21037/qims-24-348
- Citations
- 2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China